If you are Single then your Standard Deduction is $12,200 in 2019. If you made a donation to a qualified charitable organization of $12,200 and that is the Only itemized deduction on Schedule A then you would receive no tax benefit for the donation.
If you made a donation of more than $12,200 then you would receive a tax benefit since your total itemized deductions are greater than your standard deduction.
This assumes that your donation is less than 20% of your Adjusted Gross Income. A $12,200 donation would not be limited if your AGI is less than $61,000
