Yes, you should be able to Efile an Amended 2021 return. However, you don't want to do this until your original return has been processed and you have received your refund.
An Amended Return does not 'catch up' to your original return and correct it. It is processed separately. Allow at least 16 weeks for the IRS to process your amended return.
Here's the steps to filing an Amended Return.
Since we can't see your return in this forum, it's difficult to say you are unable to Efile your Amended Federal return.
You could try deleting your 1040X and repeating the process or Contact TurboTax Help.
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