OR ... since payroll withholding is considered ratably withheld evenly thru the year you could simply increase your payroll withholding to cover the "safe harbor" amount needed ... then if you have a refund you can apply it to the next year's taxes.
OR ... simply pay an estimated payment for the quarter's you actually have taxable sales.
OR ... pay estimates using the safe harbor method already mentioned.
The actual 2210 is used at the end of the year to compute possible penalties and it not really meant for the calculation of the quarterly estimated payments so it is awkward to use.
