I suggest using the following link to calculate your withholding (Form W-4)
https://www.irs.gov/individuals/tax-withholding-estimator
You can either set the money aside or have your employer withhold for you.
If you do not have your employer withhold taxes, you should file Quarterly Estimated Taxes
so you do not encounter late payment penalties.
See https://www.irs.gov/businesses/small-businesses-self-employed/estimated-taxes
Perhaps another reviewer can explain the steps to have Turbotax do this.
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