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For the federal return :  

 

Prior to the 2017 tax law changes you COULD claim the spouse's exemption if you filed separately and other circumstances applied but you could NEVER   list them as a dependent in the dependent section. 

 

Some state's may still allow personal exemptions that you can claim even if you file separately   but  you still do not list a spouse as a dependent. 

 

Which state are you referring to exactly ?