Yes, and you can set up estimated tax payments in TurboTax by typing the words estimated payments into the Search window on the upper right to get to that interview. You'll receive printed payment vouchers to send to the address on the vouchers along with payments on the date shown on the voucher.
If you use the desktop/CD version, oyu'll find this interview under Federal Taxes, Other Tax Situations, W-4 and estimated Taxes.
