And what are you trying to efile now? A state return? You might first need to update your program with the federal efile status. Go up to FILE - Electronic Filing - Check Electronic Filing Status. Then save your return, go to FILE - SAVE. Then close your return and reopen it and go though the File TAB again to file state.
There is currently a problem Efiling state. It's scheduled to be fixed on March 19. Please sign up on this Desktop state efile error FAQ
https://ttlc.intuit.com/community/tax-topics/help/why-am-i-not-able-to-e-file-my-state-return-after-...
