The penalty for underpayment of taxes is automatically added to your return based on an even income flow throughout the year. You may pay the penalty as shown on your return and not complete the Form 2210.
However, the penalty may be reduced a bit with a big chunk of income received a the end of the year and you can see that advantage by completing the interview for the Form 2210.
The penalty will not be any bigger than the original penalty that has been added to your return. It can only be reduced by the Form 2210.
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