To get your TurboTax Desktop Software to open after an update, you will need to remove the software and reinstall it. Please see this TurboTax FAQ for more information, Remove and reinstall TurboTax for Mac. What I find works, is to skip step 1, remove the other files, go back to Applications Folder, right-click, Click Open, and it should open.
If that doesn't work, some users have had success in creating a new user account on their MAC and opening their TurboTax Desktop Software from this new user account that was created.
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