Yes, you can.
You can use TurboTax Self-Employed, TurboTax Self-Employed Live, TurboTax Home & Business for Windows, and TurboTax Business to create W-2 and 1099-MISC forms for your employees and contractors.
If you're not using one of these versions to prepare your taxes, you can always use TurboTax Quick Employer Forms to e-file your W-2 and 1099s.
Instructions for TurboTax Self-Employed and TurboTax Self-Employed Live
Instructions for TurboTax Home & Business CD/Download software
Instructions for TurboTax Business
