Yes, there can be problems if you use TurboTax or save files on an external drive. You can save a copy of your tax file there after you've filed, as a back up.
Check your Task Manager to see if you have two occurrences of TurboTax running. Close both of them, restart the computer, then try opening TurboTax again. If you get the same error, you could uninstall/reinstall the program.
If you reinstall, open TurboTax and browse for the location of your tax file on your external drive to continue your return. However, you could copy the .tax2024 file from the external drive to your laptop desktop, which should make it easier for TurboTax to find.
Here's more info on Troubleshooting TurboTax Desktop Issues.
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