If you are making a QCD Qualified Chartable Contribution directly from your RMD the amount will not add to your income and not be taxed at all and the donation is not deductible. That's what I'm doing. If you are getting the RMD and making the donation separately it may or may not make a difference.
All your itemized deductions have to be more than the standard deduction to get any benefit (so you would only be getting the benefit of the amount that puts you over the standard deduction). And since the Standard Deduction is increased more people will not need to Itemize. And several deductions are limited like Medical and State taxes paid.
