No. TurboTax is an end-of-year program and so it works with full-year totals or estimates for the full-year. For example, in the "Other Tax Situations" section you can use the "Estimate Taxes" topic to estimate your taxes for the next year and create vouchers for the quarterly payments. However, the result will be generally four equal installment amounts for the total year's taxes.
However, another Intuit product, Quickbooks, does work quarterly tax estimates during the tax year. Here is a link with more details.
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