So the good news is that Ohio provides you an business income tax deduction for up to $250,000 of taxable income. This is true regardless of where it is earned.
Your Colorado situation is a bit trickier; it is a bit unclear as to whether the work you do in Colorado is remote work IN Colorado or remote work FROM Ohio to Colorado clients. I'm going to assume the second is true.
The business income you earn in Ohio will qualify for the Ohio business income tax deduction (be careful of city taxes, though - most Ohio cities have a separate city tax rate that will apply to this income AND/OR a school district tax that will apply to this income. Check your address for BOTH municipal tax and School District income tax at the Ohio Tax Finder, here: https://tax.ohio.gov/help-center/the-finder). The school district and city taxes are RESIDENT taxes, meaning that it does not matter where you earn the money, you are taxed based on where you live and the tax rate that applies there (for instance, if you live in Columbus, you will be responsible for a 2.5% city tax on your net profits from your remote work business, but no school district tax applies).
For Colorado, you will have a part-year resident return in 2022 for the partial year you spent there. You will be taxed on all income you earned while a resident; but the income you earned when you are not a resident depends on your continued connection with Colorado. Colorado uses a factor-presence standard to determine if you have "nexus" for income tax purposes that takes in to account the amount of business property, payroll and overall sales. Given that all of your sales are to Colorado, the most likely outcome of that factor-based determination is that you would owe Colorado taxes on that income. So you would report your net income from Colorado (self-employment) as a non-resident on your non-resident tax return next year and going forward.
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