Returning Member

1099-k and Schedule C

I asked two different questions on here, one was about quarterly taxes and one was about commission fee write-offs. We are live sellers making side money from selling online. One answer was yes, to make estimated quarterly payments and one was to file as a sole proprietor and deduct expenses with a schedule C form. Are these mutually exclusive or they are both relevant to my case? I was already provided the links and tools to do both (thank you!) So essentially, do I 1. estimate quarterly taxes and make direct payments to IRS AND/OR use information from a 1099-k to file a schedule C alongside personal income? Thanks in advance for any clarification!