What will i owe?

I have 4 jobs which are W2 and i got a refund last year with those. I am adding a 1099 job and need to know how much to set aside. Is there a way to do a calculator to estimate how much i will owe? I read i need to set aside 35%. How does that work? I can pay towards the taxes as often as i get paid? That would be ideal.  I am not sure how the combination of W2 and 1099 will work.