Estimated Tax Payments

I retired and had W-2 income through February 2021.  I have been drawing Social Security since January 2021.  I have a side business which typically shows a loss.

 

This year I will have 1099-MISC income from a contract job that I did.  I did not pay estimated taxes since this is my first year of retirement and I anticipate a loss from my business.  Should I make an estimated tax payment before the end of the year or wait and see if I owe any tax when my return is prepared?