@Notch352 - to be conservative, withhold 25% for federal, I can't really speak to State, but 7% is healthy for most states.
just so everyone is on the same wave length, if you take your expected 2022 income PLUS the amount you are going to take out of the IRA LESS the standard deduction, as long as the result is less than $178,150, you will not exceed the 22% tax bracket, so 25% should be a good number. If the result exceeds $178,150, the REMAINDER will be taxed at 28%, so you'll have to do the math and see where you land. Using TAXACT for 2021 to estimate is going to get you close.
Also, as pointed out by others, there is a minimum that you must take every year. There is a lot of confusion about that as the law changed in 2020 and the IRS has not created the final rules. what we do know is that there is a requirement for the beneficiary to distribute a minimum about, based on the IRS table, but due to all the confusion, the IRS will not penalize anyone who fails to do so in 2021 and 2022, so ineffect if you take out zero, you are fine for these years - no harm no foul.
Here is a link to the 'plain English' explaination and the article includes a link to the "IRS hard to understand" version
https://smartasset.com/retirement/penalties-waived-on-some-missed-rmds
