Under the proposed regulations you are required to take annual distributions beginning with 2022 based on your life expectancy from the Single Lifetime table based on your age attained in 2022, reduced by 1 each subsequent year, and fully drain the IRA by the end of 2031. Your sister is required to do the same using her age.
Notice 2022-53 waives the penalty for not taking the 2022 beneficiary RMD. However, it does not actually waive the requirement to take the RMD for 2022, although eliminating the penalty means that there is no consequence to not taking the distribution (other than not reducing the balance in the inherited IRA). As others have said, though, to avoid a large bump in taxable income in any one year it might be best to take roughly equal distributions over the 10-year period, beginning with 2022, unless you anticipate your other taxable income being less in later years of the 10-year period.
