You would sign the form if you were submitting this as a stand alone document. If you are sending an amended return, then this wouldn't be signed.
With this said, I don't think it will make much of a difference to the IRS. Since you are mailing the return, you may wish to put in a note and attach it with your amended return stating you accidently signed it before reading the instruction. I should suffice as it won't make a difference one way or another.
@bill12215
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