Unanticipated capital gains

I have a question on unexpected capital gains for 2022 tax year.  My wife and I are both unemployed.  We took some money out of our IRA's this year with a withholding rate of 20%.  We do not make estimated tax payments since I assumed the withholding would be sufficient.  In July of this year, a company that I had stock in went private.  They paid out all of my shares in cash but did not withhold any tax.  I have a sizeable capital gain as a result.  I am trying to figure out how I determine if I need to make some type of estimated payment now to avoid any tax penalty.   Any suggestions?