Yes, you can use TurboTax Deluxe CD (or download) version to report the sale of a primary residence, and report Capital Gains if necessary.
However, if you sold your primary personal residence and you lived in and owned the home for at least two years in the five year period prior to the date of sale, you do not have to report the sale if your gains are less then the exclusion amounts of $250,000 if filing Single or $500,000 if filing Married Filing Jointly.
Click this link for more info on Sale of Personal Residence.
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