You may NOT take a full exclusion on the gain.
First, you must recapture (pay tax on) the depreciation "allowed or allowable" (claimed or shoulda been claimed). Second, you must prorate the other gain between rental time (non qualified use) and principal residence time (qualified use)*.
When you enter the home sale in Turbotax (TT), and follow the interview carefully, TT completes the "Home sale work sheet" to handle that complex calculation of the partial home sale exclusion, non qualified (rental) use capital gain and depreciation recapture.
*A period of nonqualified use does not include: Any portion of the 5-year period ending on the date of the sale or exchange AFTER the last date you (or your spouse) use the property as a main home. That does not appear to be your situation.
