If I have $100,000 in capital gains, then I lose ALL my money from a bad investment, do I still owe taxes on the $100,000 capital gains even though I have 'no money'?

I am referring to short term capital gains in the stock market. If I make a great trade, then it's followed up by a bad trade (total loss of whole account value), how am I expected to pay taxes on the $100k in capital gains?