crypto tax loss harvesting

Hello community.

I was familiar with the term tax loss harvesting, but it seems like it is a strategy that I will need to implement this year. Crypto does not have a wash sale rule unlike stocks. 

 

How does it work with realized loss on crypto vs ordinary income from W2 or 1099? 

Say for example:

You made $300,000 W-2 pre-tax income, but your crypto realized losses are $50,000. 

Does tax loss harvesting mean, you can offset your regular taxable income?