Based on your description, yes she would qualify for the $250,000 exclusion.
If you sell your main home, and have a profit, you may qualify to exclude up to $250,000 (if single) from your income, or up to $500,000 if you file a joint return with your spouse.
You can meet the ownership and use tests during different 2-year periods. However, you must meet both tests during the 5-year period ending on the date of the sale.
IRS Sale of home exclusion
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