You need to use the Form 1099-S to report the sale of a second home. Any gain on the sale will be investment income, taxable as capital gain income. Any loss will not be deductible since it is personal use property.
Follow these steps to enter the sale in TurboTax:
1. Navigate to Investment Income in the Wages and Income section of TurboTax
2. Choose the Stocks, Cryptocurrency, ... option
3. Skip the Import option
4. Choose the Other (land, second homes, personal items) option for investment type
5. On the screen where you enter the sale information, choose Second Home for the investment type and complete the rest of the entries
The mortgage interest is deductible as an itemized deduction. You can enter it in the Deductions and Credits section, then Your Home and then Mortgage Interest. It will only benefit you if you benefit from itemizing your deductions. Other than that, you don't need to report the Marriott purchase.
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