Are you asking about Form 1098 for mortgage interest or Form 1098-T for tuition? If you are asking about Form 1098-T see the answer from Hal_Al above.
If you are asking about Form 1098, box 10 can be used for many different things. One of the common things it might show is the amount of real estate tax that the lender paid to the municipality. If that's what it is, enter the amount in the box for "Property (real estate) taxes paid on the screen where you enter the 1098. If it's anything else, it's probably just for your information and does not have to be entered in your tax return.
