Generally, no. That's because in order to claim education expenses, he would have to be listed as a dependent on your tax return. However, if your son files his own tax return as Married Filing Separate, and he does NOT take his self-exemption, then you can claim him as your dependent and claim the education expenses.
Another thing too that's important. If your college student is the primary borrower on the loan, then depending on the amount of the loan you may not qualify to claim him as a dependent at all, regardless of his marital status. Hopefully, you the parent are the primary borrower. If the latter is true, then no need for me to go into detail.
