You will need to calculate business expenses, including employee wages and pensions (if any), vehicle expenses, advertising, supplies, home office, and more.
Here is a link with detailed explanations and items to be sure to deduct:
Taking business tax deductions
Additionally, here is a link regarding Self-Employed tax tools which will be a great resource for you.
Quarterly estimated tax information:
Self employed independent contractors typically do not have tax deducted from their pay. If you have a tax liability the IRS requires you file quarterly estimated tax payments on Form 1040ES. The estimated tax payments are based on an estimation of your income for the current year.
Estimated tax payments IRS 1040ES tips
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