My wife is self employed cleaning houses. If she has an office in our home is her mileage deductible to her clients? Don't know if office in home makes a difference.

Mileage question was answered without me referencing office in home.  That answer was that the mileage was not deductible.  When she was a sales rep we had an office in the home and her mileage was deductible to clients but not the return trip.  Not sure if having the office makes a difference or not.