It depends on all of your Schedule A deductions (itemized deductions.) Your donations by themselves wouldn't have to exceed the standard deduction, but the total of ALL itemized deductions would need to exceed the standard deduction for them to count. i.e., your allowed medical expenses, taxes, interest, donations, and the 2% miscellaneous deductions would have to total more than the standard deduction for them to start to count.
Medical deductions are further limited. Only the amount of medical expense over 10% of AGI will count on Schedule A (7.5% for those filers age 65 or older.)
