It is all based on the income of your business. The home office deduction is limited each year to the profit of the business. In other words, the home office can't help you get a bigger loss.
If your gross income from the business use of your home equals or exceeds your total business expenses (including depreciation), you can deduct all your business expenses related to the use of your home.
If your gross income from the business use of your home is less than your total business expenses, your deduction for certain expenses for the business use of your home is limited.
IRS Pub 587 (page 9):
https://www.irs.gov/pub/irs-pdf/p587.pdf
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