First of all, the donation must be to an IRS-defined qualified organization.
Please describe the donation. What kind of donation--cash, items, stock, etc.?
It may have certain record-keeping requirements. What is the approximate value?
Some large donations require an appraisal.
You'll likely get some comments in this forum today. In the meantime, here's some information about charitable contributions in IRS Pub. 526:
<a rel="nofollow" target="_blank" href="
https://www.irs.gov/publications/p526">https://www.irs.gov/publications/p526</a>
