No. Electing to take the Standard Deduction when it is more beneficial for you to do so, will not by itself raise a flag with IRS. If you decide to itemize your deductions next year, rather than take the Standard Deduction you are free to do so, as well.
Even if you do decide to take the Standard Deduction, this year, since you are self-employed, you may still take a deduction for home office expenses and allocate your mortgage interest (if applicable) and property taxes, etc. as you have in the past.
