whether you take itemized deductions or the standard deduction this has not to do with the home office deduction (HOD). Generelly, the HOD is not available to employees. Otherwise, one year you can use the simplified method and next year to the actual expense method (AEM) with the AEM you'll need to keep track of the depreciation you take because that is subject to recapture on the sale of the property. TurboTax will not track this if you change methods.
