Deductions & credits

If you are an employee, no.

 

If you are self-employed, probably no.  Your home office must be your main place of business.  If you have an office or normal job site you could go to, that is your main place of work and you generally don't qualify for the home office deduction.  There are some exceptions and the rules are discussed here.

https://www.irs.gov/publications/p587