The reason you are asked about claiming a Home Office Deduction when you sell your home, is that you may have taken a depreciation expense when you claimed home office expenses, which would change the Cost Basis of your home in reporting the sale and/or gain or loss.
However, if that was the case, Form 8829 would have been a part of your return, whether you qualified for the deduction or not.
If you are W-2 employees, you may have claimed a deduction, prior to 2017, after which the home office deduction was no longer available for W-2 employees.
Other than that, the Home Office Deduction has not changed substantially, and the amount of depreciation that you may have claimed would not impact the sale of your personal residence, with the Home Sale Exclusion applied.
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