Did you sell your home in 2022 or in 2023. If it was in 2022, it's too late to do anything to reduce the tax. Use some of the "very large profit" to pay the tax that you owe.
If you sold your home in 2023, and you own stock or other investments that have declined in value, sell them in 2023. The investment losses will offset some of the profit on the home.
