If your taxable income is zero with the standard deduction, it really doesn't matter what your itemized deductions are. Once your taxable income is down to zero, it will not go any lower.
However, you should also realize that there are limitations on many of the itemized deductions. For example
- Medical: you can only deduct unreimbursed medical expenses that exceed 7.5% of your adjusted gross income (AGI), found on line 11 of your 2022 Form 1040.
- Mortgage Interest: the loan limit is $750,000. That means for the 2022 tax year you could only deduct the interest on mortgages up to $750,000.
- State and property tax deduction: Taxpayers can't deduct more than $10,000 in state and local levies on their federal returns.
- Charitable deductions: Your deduction for charitable contributions generally can't be more than 60% of your AGI, but in some cases 20%, 30%, or 50% limits may apply.
These are just the most common limitations, in addition, many formerly deductible expenses no longer qualify.
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