Look at Form 4562 for the last year you claimed a Home Office Deduction for the Prior Depreciation and Current Year Depreciation and add those amounts together.
In the Home Sale section, enter this amount when TurboTax asks for it, after you indicated that you had a Home Office.
Your 100K profit on the home sale will be excluded, but you will have a taxable Gain of the Depreciation amount which can be up to 20% for a Long Term Capital Gain (depending on your income).
Look at the Home Sale Worksheet, Line 30 in FORMS mode to see the calculations.
You are correct that taxpayers should keep in mind the recapture of Home Office Depreciation when selling their home.
@Ultry135
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