To start with, I would take this to a tax professional. The exclusion for the sale of a primary residence is a big deal and there is no reason why you should not get it for both you and your spouse provided you are both citizens and she had the home listed as her primary residence and was only unable to live there due to travel restrictions.
If there are issues with your wife's citizenship then that may make a difference as well.
If you are going to continue with self-preparation then I advise you to enter the home for the exclusion into your tax return and try adding a letter to the IRS explaining your situation and then mailing your return instead of filing electronically. It will significantly delay whatever refund you are due but it will be the safest way to deal with this.
@jeffo45
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