No. A payoff is never deductible.
Typically, when a vehicle is not 100% business use, you claim the "per mile" deduction to deduct for each "business" mile driven. The vehicleis entered in the Business Vehicle asset section. If so, you're probably already claiming the per-mile deduction. For 2022 you'd be claiming 58.5 cents per mile, of which 26 cents per mile is depreciation.
You may be able to claim a percentage of the interest paid on the loan for the entire tax year, equal to the percentage of business use for that year.
Basically, when you enter the business miles driven, the program (not you) will do the math to figure the amount you can actually claim against the business income.
