Income section "1099-MISC and Other Common Income" does not address the 1099-S. A search for it or "sale of a second home" does not provide information other than what pertains to the sale of a primary home. The "Investment Income" section pertaining to 1099-B or broker statements" likewise does not address the sale of a second home. I believe previous versions of TurboTax Premier did address 1099-S.
