Yes, if your home office qualifies as a tax deduction you can use an RV and also claim expenses to maintain the office. Any mileage that is required to earn your self employment income would be allowed as a deduction.
The information provided below will allow you to determine if you meet the requirements to deduct a home office for your business. Also included is a TurboTax FAQ for business mileage.
https://ttlc.intuit.com/replies/3302005
https://ttlc.intuit.com/replies/3302360
