If you are a W-2 paid employee, there are no job expenses allowed to be taken. They disallowed the Form 2106 deduction for employees a couple of years ago.
Please be aware that if you go to another state on vacation and work for someone in that other state, it is generally likely that any income you receive from working in that other state will be taxable to that other state and you will have to file an income tax return with that other state as well as claim the income on your resident state return.
If you are self-employed, but have a work location where you meet with customers and conduct most of your business, then a home office deduction probably will not be able to be taken, depending on the circumstances.
