Yes, you can use your Home and Business to prepare the W-2's and 1099 forms for your church. Make sure that you start a new return so that the church information is in a separate file from your personal data.
Also be aware of the new 1099-NEC form for 2020. That form takes the place of Line 7 on the 1099-MISC form. If you are preparing 1099's for employees, then use 1099-MISC. If for sub-contractors, use 1099-NEC.
Here is an article about the new 1099-NEC form.
