No, according to the IRS in Income & Expenses 6 | Internal Revenue Service:
The federal government charges excise taxes on the sale or use of a wide variety of products. An excise tax isn't deductible if it's for a personal expense. You can deduct as a business expense excise taxes that are ordinary and necessary expenses of carrying on your trade or business.
Excise tax paid to your state and local for sale of home would not be business related so not deductible.
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