Yes, you may file your income tax return, but it will be stockpiled. There are federal forms that may still not be available.
The deadline for making a payment for the fourth quarter of 2020 is January, 15, 2021.
The IRS starts accepting application by February 12, 2020. On this date, IRS will also starts processing stockpiled returns on a first in, first out basis.
See link, e-file question, for additional information.
