There is no "self-employed medical deduction." There is only a self-employed health-insurance deduction for the premiums for a health insurance plan established under the business (or in your name). Other than health insurance premiums paid after you reach age 65, continuation coverage under COBRA and health insurance coverage while receiving unemployment compensation, health insurance premiums cannot be paid from your HSA, so, generally, what can be paid from your HSA is entirely distinct from what can be deducted on Schedule 1 line 16.
Are you asking about medical expenses other than insurance premiums, about insurance premiums that are permitted to be paid with an HSA distribution, or something else?
